Delayed gadolinium-enhanced magnetic resonance imaging of cartilage or dGEMRIC measures the fixed-charge density and relative proteoglycan content of

The dGEMRIC index was lower in SCFE hips than unaffected hips 456 ms (CI 419–493) vs 521 ms (CI 476–567) (P = 0.03). The difference was larger (mean 21 ms) in anterior than posterior regions of the hip (P = 0.038). The alpha angle was higher in SCFE hips, 61.5° (CI 53.9–69.1) vs 45.6° (CI 43.6–47.6), (P < 0.001).

2014-11-01 Those who decreased their physical activity showed a significant decrease in dGEMRIC index in the medial weight-bearing cartilage. Conclusions: The higher pre-contrast T1 in the superficial region than in the deep region is an indication of a higher water content in superficial cartilage. The dGEMRIC index has been shown to be affected by factors, such as exercise , body mass index , and early-stage OA . This imaging method has been validated in clinical studies comparing histological and biochemical measurements of GAG content ( Figure 9 ) [ 104 ]. The dGEMRIC index in the group below 50 (no FAI) was higher than in the group with an alpha angle above 65 (consistent with FAI, P ¼ 0.026). Furthermore, the total dGEMRIC index in SCFE hips correlated inversely to the alpha angle (P ¼ 0.046, R ¼ 0.40) (Fig.

Dgemric index

BMJ, British dGEMRIC, gadoliniumförstärkt magnetisk resonansbildning av brosk. trastförstärkt MR (dGEMRIC), där man försöker mäta kvalitet på brosket, index-patellarsenorna noterades ett mer heterogent ECM med slumpmäs-. DGEMRIC-indexet korrelerar med proteoglykaninnehåll i brosk och minskas i OA, i överensstämmelse med vävnadsglykosaminoglykanförlust [ 35, 36]. I tidig OA T1-mätningen efter penetrering av Gd-DTPA 2- benämns dGEMRIC-indexet. Broschområden med lägre dGEMRIC-index observeras vanligtvis i leder där som T2, T1rho, ultrashorteko och dGEMRIC-tider ännu inte klart fastställda 12, 13 .

The patients were divided into two groups on the basis of their dGEMRIC index. This division was established by ﬁrst calculating the mean and SD of the dGEMRIC indices of all of the study cohort patients. Then patients were grouped according to whether they were less than one SD or at least one SD below the mean dGEMRIC index of 426 msec.

Then patients were grouped according to whether they were less than one SD or at least one SD below the mean dGEMRIC index of 426 msec. The dGEMRIC indices, with and without BMI dose correction, for each of the 4 ROI and averaged for each sagittal section are presented in Table 2.There was statistically significant negative correlation between age and dGEMRIC index regardless of BMI dose correction (medial dGEMRIC index, r = −0.40, p < 0.001; lateral dGEMRIC index, r = −0.29, p = 0.012). dGEMRIC index with quantitative measures of proteoglycan content and with semi-quantitative histologic scores3. A lower dGEMRIC index has been associated with regions of hyaline * Address correspondence and reprint requests to: T.E. McAlindon, Division of Rheumatology, Center for Epidemiologic Based Research, Tufts Medical Center, Box We performed a prospective cohort study to evaluate the dGEMRIC index of articular hip cartilage and the morphologic changes in the labrum, cartilage, and bone preoperatively and at twelve and twenty-four months following periacetabular osteotomy for correction of developmental dysplasia of the hip.

29 Jun 2011 Thereby, subsequent T1 measurement in cartilage described as dGEMRIC index or T1Gd reflects the GAG content within a certain cartilage

In the current dGEMRIC protocol, Gd-DTPA 2− is administered per kilogram body weight with the assumption that the distribution volume of the contrast agent is proportional to body weight. The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index is highly correlated to mechanical stiffness, and, although not as good as a direct mechanical measurement, the index can be used BACKGROUND Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an objective, noninvasive, and longitudinal quantification of biochemical cartilage properties.

Results: The mean dGEMRIC index (and standard deviation) for this cohort (473 +/- 104 msec) was significantly lower than that of a morphologically normal hip (570 +/- 90 msec). The anterior center-edge angle, the joint space width, and the presence of a labral tear were all found to be associated with osteoarthritis in the univariate analysis. Acetabular dGEMRIC indices were measured on the 7 clock positions of the superior circumference (9 to 3 o’clock). 51 Femoral dGEMRIC indices were measured on the concordant 7 clock positions.
Piktogram kemikalier

The CAL index 19 Aug 2015 Our study aimed to determine whether dGEMRIC indices are predictive of Twelve of the sixty-four hips had a dGEMRIC index of <323 msec 19 Jul 2020 Objective To determine the association between changes in the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) index over 2 years as 10 Nov 2016 (3) Is there a correlation between the baseline dGEMRIC index and the change of dGEMRIC indices of femoral and acetabular cartilage were dGEMRIC (delayed Gadolinium Enhanced MRI of Cartilage) is a technique for T1(Gd), has been used as the dGEMRIC Index in a number of studies to Conclusion: The lower dGEMRIC Index of the medial compartment suggests decreased cartilage GAG content after medial meniscectomy, indicating an early Preoperative delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) for patients undergoing hip arthroscopy: indices are predictive The dGEMRIC index could not be calculated for 8 regions in the injured knee in 5 patients and for 1 region in the uninjured knee in 1 patient, due to marked 10 Apr 2007 Can nondestructive MRI provide a measurement of cartilage function? The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index Delayed gadolinium-enhanced magnetic resonance imaging of cartilage or dGEMRIC measures the fixed-charge density and relative proteoglycan content of 6 Nov 2013 Study protocol.

* Address correspondence and reprint requests to: T.E. McAlindon, Division of. Rheumatology dGEMRIC.
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13 Oct 2017 resulting dGEMRIC index (the average T1Gd in a region of interest) is related to both the GAG concentration and the time between gadolinium

Use of the dGEMRIC index as a predictive measure of stiffness is possible, depending on the application's acceptable error. Thus, a higher dGEMRIC index indicates healthier cartilage (Fig.

dGEMRIC baseras på hypotesen att ett negativt laddat kontrastmedel, RIC-index löpte större risk för att ha utvecklat knäartros liksom att

average dgeMriC indices (in Milliseconds) for the 12 regions of interest, the Medial and lateral Compartments at Baseline and after Follow-up. - "Cartilage Quality (dGEMRIC Index) Following Knee Joint Distraction or High Tibial Osteotomy" Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) reflects cartilage glycosaminoglycan (GAG) distribution. The technique assumes that the plasma levels of the contrast agent Gd-DTPA2− are the same across individuals after intravenous (IV) injection, when dosing by weight.